Superstars Al Ewing and Javier Rodriguez reunite for a cosmos-colliding journey! When existence itself faces extraordinary threats, it needs an extraordinary defense! That's when you call...the Defenders! Doctor Strange and The Masked Raider gather a non-team of Marvel's weirdest, wildest heroes for a mission that will uncover the hidden architecture of reality itself! This cosmos was not the first to exist...but, if the Defenders can't track Marvel's oldest villain through the deepest trenches of time, it might be the last! The group must travel to the long-extinct previous cosmos, the birthplace of Galactus - but the Devourer is not the man they remember. Meet Taaia, Omnimax and more as Marvel history expands...and Doctor Strange's makeshift Defenders face extreme jeopardy!